Research & Training Opportunities

INTRODUCTION & DESCRIPTION OF PROJECTS

The projects summarized below will allow the trainees to translate the skills of the Training Program and to develop a thorough knowledge in basic, clinical and translational research. The proposed topics include advanced imaging in disease and novel technology developments, patient-based translational research through novel technologies and unique resources, functional genomics, genetics, basic cancer research, apoptosis and new treatments, and developmental biology. There is ample room for creativity and innovation, especially in the development of novel technologies, software, bio-markers, and possible treatment protocols. All approaches are unique in that they tackle current challenges in health sciences through innovative methods and complement them with the strong expertise of each mentor in a transdisciplinary manner.

Projects that involve foreign mentors will be rotations or short- vs. long-term projects that are carried out in collaboration with Canadian mentors. The Program Coordination Committee will assure the best possible training environment for the trainees in the program.

Candidates For This Program

Our training target groups are graduate level students in basic sciences, medical students, MD/PhD students, residents, clinical fellows, clinician-scientists, visiting fellows, clinical geneticists, technicians and research associates. In addition, high school students, their teachers and public education are firm pillars of the training program.

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COURSES

ADVANCED MOLECULAR IMAGING

Course Details & Photos: Principles of Microscopy and Imaging

Mechanisms of disease: Imaging in disease and new technology developments.

a) Infrared spectroscopy and spectral imaging in Alzheimer’s disease. K. Gough.

b) Development of new technologies.

S. Mai

PATIENT-BASED TRANSLATIONAL RESEARCH WITH NOVEL TECHNOLOGIES & RESOURCES

a) Microarray expression and CGH analysis of ovarian and prostate cancer.

J. Squire.

b) Defining molecular markers to improve diagnosis and disease management in breast cancer using the Manitoba Breast Tumor Bank.

P. Watson.

c) Mechanisms of lung cancer progression and drug resistance in Non-Hodgkin’s Lymphoma.

M. Mowat.

d) Oncogenes in cellular transformation, cell cycle and apoptosis.

T. Fest.

FUNCTIONAL GENOMICS

Functional genomics.

G. Hicks.

GENETICS

Gene discovery in genetic diseases.

B. Triggs-Raine.

BASIC CANCER RESEARCH

a) Cellular transformation and histone modification.

J. Davie.

b) Molecular mechanisms of hormone dependence and progression in human breast cancer.

L. Murphy.

c) Functional anlysis of TLS in genomic instability and DNA repair:

G. Hicks.

d) Genomic instability and c-Myc.

S. Mai.

e) Functions of telomerase.

P. Boukamp.

f) Cellular transformation and neoplasia.

F. Mushinski.

APOPTOSIS AND NEW TREATMENTS

a) Mechanisms of apoptosis and development of novel treatment protocols in cancer. S. Gibson.

b) Genetic control of drug induced apoptosis.

M. Mowat.

DEVELOPMENTAL BIOLOGY

Neuronal differentiation during development and pediatric malignancies.

D. Eisenstat.